Jones (1997) reports that mechanical and chemical methods are the primary means of control.
Physical: Seedlings and young plants, up to about 1.5m tall, may be hand-pulled as long as their root systems are small and can also be removed. Care should be taken not to disturb the soil any more than necessary.
Chemical: The application of a 10% solution of triclopyr (e.g., Garlon 4) in a band around the base of the trunk (basal bark method) or application of a 50% solution of the same (e.g., Garlon 3A) on a freshly cut trunk (cut stump method) are the most effective ways to kill adult plants. The application of a 3% solution of triclopyr to the foliage (foliar application method) may be used if non-target vegetation in the immediate vicinity will not be impacted by herbicide drift. Because of the possibility of resprouting from the rooted portions of the plant, follow-up inspections and retreatments may be necessary for a year (if not longer) following the initial treatment. In addition, the long viability of seeds in the soil requires monitoring of treatment sites for several years after the initial treatment.
Biological: Schultz (1992) cites that biological control of C. Asiatica needs to be investigated. Apparently no research is currently underway or planned (Dan Austin, pers. Comm. 1992, Langeland 1990, in Schultz, 1992). However, because both the genus Colubrina and the family Rhamnaceae contain native species as well, biocontrol efforts directed at C. Asiatica should be approached cautiously.